Title: Producing a Formulation, Differentiating between Distress and Disorder, Psychosomatic Disorders
1Producing a Formulation, Differentiating between
Distress and Disorder, Psychosomatic Disorders
- Dr. James Rodger
- Consultant Child Adolescent Psychiatrist, South
Devon CAMHS
2Overview
- Differentiating distress from disorder what the
manuals tell us - Beyond impairment models of disorder
- Validity of mental disorder
- Formulation
- Somatisation
3Differentiating between Distress and Disorder
4Correct answer?
- DSM-IV-TR
- polythetic symptom criteria
- episode fit (is there a better fit?) /
developmental criteria / duration criteria - causing clinically significant distress or
impairment (educational, occupational, social,
family life) - D diagnostic fit (superordinate diagnosis,
organic causes excluded?)
5Case example - ADHD
- The DSM criteria - two groups
- Inattentive (9) and hyperactive-impulsive (63)
symptoms (inconsistent with developmental level) - Six of the nine symptoms in each section must be
present for a combined type diagnosis of ADHD. - if insufficient symptoms for a full diagnosis
- predominantly inattentive (ADHD-I)
- predominantly hyperactive (ADHD-H)
- Supported by factor-analysis studies
- most studies supporting a two-factor model of
symptom clustering (as above)
6DSM-IV-TR
- symptoms must be chronic (gt 6 months) and present
before age 7 - symptoms present in 2 or more settings but
evidence of significant impairment required in
only one setting (social, school or work) - not occuring exclusively in context of PDD or
psychosis, not better accounted for by another
disorder (e.g. Anxiety, ?RAD)
7ICD-10 hyperkinetic disorders
- Almost identical symptom list but need symtom
count in all 3 domains accross gt2 contexts - 6/9 inattentive
- 3/5 hyperactive
- 1/4 impulsive
- Significant distress or impairment 1 or more
contexts - More rigourous exclusion (psychosis, PDD, mood,
anxiety) - Prevalence rates much lower (lt50) using ICD
8Prevalence - UK
- British Child and Adolescent Mental Health Survey
1999 (ngt10,000) - parents / teachers impairment (?clinical
process) - 3.62 of boys and 0.85 of girls had ADHD
- 4.251 MF.
- more restricted diagnosis ICD10-hyperkinetic
? ?prevalence ?1.5 for boys (primary school)
9Natural Rates of ADHD!
- UK prevalence estimate up to 16 (Taylor 1991)
- In USA prevalence estimates 8-25
- Worldwide high variability (DSM-IV)
- Low Australia 2.4 10 (DSM-IV
- High Brazil, Colombia, Germany, Ukraine 15-20
- majority of variability ? methods used
- Criteria
- Rating scales vs. more in depth interview
- Impairment
- Sources of information (single / multiple)
- minor differences worldwide (NICE) 5.3
10Impairment
- Fundamental to diagnostic validity (as ADHD
symptoms on spectrum with normal population) - Without criterion of impairment ? 2x ? prev
- Newcastle (McArdle et al., 2004).
- 11 if no impairment
- 6.7 moderately low impairment
- 4.2 for moderate impairment
- 1.4 for severe pervasive impairment
11Is distress and/or impairment enough?
- Being gay can be very distressing, if you, or
your family, or wider society dont want you to
be but we dont call homosexuality a. err
burn the previous editions - Roland Littlewood a psychiatrist and
anthropologist describe a woman in her 30s, who
by our standard would have met all several
criteria for schizophrenia, but was not
distressed, and formed a new religious movement
Mother Earth with many followers - therefore
no dsyfunction?
12Biomedical Definitions
- biological disadvantage (Scadding 1967)
- that it must at least encompass reduced fertility
and life expectancy (Kendell (1975) - Are we happy for this to be our primary
evaluative criterion for thinking about the value
of human life? - Life style choices, homosexuality, and life
within religious orders, may all be patholgised
by such a definition! - Illogical consequences when applied to thinking
about mental disorder - Many milder conditions such as phobias as well as
disorders with onset after the prime reproductive
years would fail to qualify as disorders and may
not affect life-expectancy either - Conduct disorder may confer evolutionary
advantage!
13Biomedical Disadvantage Failure of
Evolutionary Design?
- dysfunction - failure of a biological mechanism
to perform a natural function for which it had
been designed by evolution (Wakefield 1992) - Too little known about the evolution of most of
the higher cerebral functions - Mood states such as anxiety and depression may
have evolved as biologically adaptive responses
to danger or loss - Paranoia ,hearing voices OCD, may have
conferred evolutionary advantage, during EEA
(Pleistocene 1.8million 12,000 years ago) - Some cognitive abilities, like reading, have been
acquired too recently to be plausibly regarded as
natural functions designed by evolution
14Can dysfunction be defined without reference to
evolution or disadvantage?
- too little is known about the cerebral
mechanisms underlying basic psychological
functions, such as perception, abstract
reasoning, and memory, for it to be possible in
most cases to do more than infer the probable
presence of a biological dysfunction?? - i.e. need a frame of reference to say whether
pathology - Furthermore, rejecting both the evolutionary and
biological disadvantage criteria may open the way
to regarding a wide range of purely social
disabilities (such as aggressive, uncooperative
behaviour or an inability to resist lighting
fires or stealing) as mental disorders. - Is this already happening?
15Sociopolitical Definitions
- disease is simply what doctors treat!
- Although rarely advocated by physicians -
treatability is often a crucial consideration
underlying their decisions to regard individual
phenomena as diseases - despite the advocacy of Thomas Trotter and
Benjamin Rush at the beginning of the nineteenth
century and a sustained campaign by Alcoholics
Anonymous in the 1930s, the medical profession
firmly resisted the proposal that alcoholism
should be regarded as a disease until disulfiram
(Antabuse) was introduced in the late 1940s - As for Ritalin and ADHD gtlate 1960s?
16Sociopolitical Definitions
- Condition is regarded as a disease if it is
agreed to be undesirable (an explicit value
judgment) and if it seems on balance that
physicians (or health professionals in general)
and their technologies are more likely to be able
to deal with it effectively than are any of the
potential alternatives, such as the criminal
justice system (treating it as crime), the church
(treating it as a sin), or social work (treating
it as a social problem). - essentially pragmatic or utilitarian.
- given condition might be a mental disorder in one
setting but not in another - depending on the
relative efficacy of medical and other approaches
to the problem in those different settings
17Sociopolitical Definitions
- whether restless, overactive children with short
attention spans are regarded as having
attention-deficit/hyperactivity disorder or
simply as being difficult children would depend
on whether child psychiatrists were better at
ameliorating the problem than parents and teachers
18Combined biomedical and sociopolitical definition
- concept of mental disorder necessarily involves
both a scientific or biomedical criterion
(dysfunction) and an explicit value judgment or
sociopolitical criterion harm (Wakefield
1992/99) or handicap (WHO) - meets the main requirement of both the
sociopolitical and the biomedical camps - seems to reflect the often intuitive ways in
which physicians make disease attributions for
physical disease - value judgements may vary accross cultures, and
would be important even if concrete biological
substrates discovered - Nailing down assured biological dysfunction, may
still be elusive, and definition may slide
towards purely sociopolitical definitions, masked
by pseudo-science? - ODD...CD.... .....(ADHD?)
- Also c.f. Neurodiversity Movement
-
19ADHD as a case example controversies
- ADHD is total, 100 percent fraud Fred
Baughman - Pediatric neurologist (2006) - ADHD is real, a real disorder, a real problem,
often a real obstacle Russell Barkley, leading
ADHD researcher (1995) - you ask me, any kid who would rather go outside
and play, than to sit in school all day sounds
pretty normal to me (Yahoo Questions 2008).
20The place of values
21Who is it a problem for?
- cultural differences in the level of activity and
inattention that is regarded as a problem
(Sonuga-Barke et al., 1993) - teachers and parents tolerance and ability to
cope may determine whether the hyperactivity is
presented as a problem - Children with hyperactivity rarely ask for help
themselves
22Male Female
- Clinic referred 101
- Community referred 31
- Disruptive behaviour drives referrals?
23An androgenist critique
- Quantified Observation
- ethological observation and activity monitoring
confirmed that teachers more likely to attribute
symptoms of ADHD to boys than girls after
correction for actual behaviour differences
(Brewis et al. 2003) - Mothers and female teachers statistically more
likely to initiate process of diagnosis and
treament for ADHD, than fathers / male teachers
who may view behaviour as more normative
24Case Study homosexuality
- Sexual Orientation Disorder (DSM-II revision
1974) / Ego-dsytonic homosexuality (DSM-III 1980)
located the problem within the psychologies of
gay people, rather than within the society who
stigmatised and discriminated against them - DSM-IV (1994) ego dystonic homosexuality
dropped, but included "sexual disorder not
otherwise specified" which could include
"persistent and marked distress about ones
sexual orientation."
25Challenges to this definition
- Therapeutic challenges
- Recovering subjugated narratives of strength
- Explicating social causes of suffering (poverty,
discrimination etc.) - Diagnostic challenges
- Relational Disorders in DSM-V but limited scope
(e.g. domestic violence, post-partum depression) - Political challenges
- Neurodiversity
- Critical Psychiatry
26Ostensive Definition
- Impossible, even in principle, to provide a
semantic or operational definition of the
global concept of mental illness or disorder,
only of individual illnesses or disorders
(Lilienfeld and Marino 1995) - The only criterion available is whether putative
or candidate disorders are sufficiently similar
to the prototypes of mental disorder (e.g.
schizophrenia and major depressive disorder) - The best definition remains a circular one!?
27Levels of Explanation
- Even physical disease cannot be defined by one
overaching definition - Clinical syndrome migraine and torticollis
- Morbid anatomy mitral stenosis
- Histopathology tumours
- Chromosomal architecture Down syndrome
- Molecular structures thalasemmias
- what is the most useful level of explanation
(utility!) yielding the most useful information
for action for a given presentation - May be reciprocally influenced by treatment
available. Current treatments for torticollis
dont demand a molecular level understanding,
even if this was available
28Why are different levels of explanation required?
- more a particular presentation looks similar to
others but responds differently - the more
complex the level of explanation needs to be? - Most psychiatric disorder still defined by
clinical syndrome current drug treatments dont
justify a more complex biological description - But they do justify a more complex psycho-social
/ systemic description e.g. diffential
explanations for symptoms of hyperactivity and
inattention
29What do we mean by validity?
- valid validus strong
- defined as well founded and applicable sound
and to the point against which no objection can
fairly be brought - Logic validity is the characteristic of an
inference that must be true if all its premises
are true. - there is no single, agreed upon meaning of
validity in science, although it is generally
accepted that the concept addresses the nature
of reality - its definition is an epistemological and
philosophical problem, not simply a question of
measurement - diagnostic vs. nosological validity
30Establishing Validity Feigner Criteria
- Robins Guze (1970) / Feighner (1972)
- Clinical description
- Labaratory Studies (i.e. to show biological
dysfunction includes cognitive profile?) - Delimitation from other disorders (c.f. zone of
rarity Kendell 2003) - Follow-up studies (diagnostic stability
response to Rx and outcome) - Family studies
31Diagnostic Validity(According to NICE)
- Do Symptoms of inattention, hyperactivity
cluster together - Can they be distinguished from normal variation
in the population? - Are they distinguishable from other disorders
- Are symptoms asociated with significant clinical
and psychosocial impairments? - Are there characteristic outcomes?
- Is there consistent evidence of genetic,
environmental or neurobiological risk factors? - Risks overlap / confluent with risks in normal
population depending on method used
32Different Validators Different Answers
- a hierarchy of validators must first be chosen
for a given nosologic question - involves a value judgment and cannot be directly
addressed by empirical inquiries - What is the core feature of schizophreniathat
it has a poor outcome, its Sx or that it runs in
families? - This is not a scientific question.
- only once nosological question is set, can task
of formulating maximally valid diagnostic
criteria even begin to occur - Could compare different diagnostic criteria for
utility, in different contexts - DSM-V may rate relative validity of different
diagnosis but based on what?
33Validity vs. Utility (Kendell Jablensky 2003)
- Few psychiatric diagnosis can claim nosological
validity, according to Feighner criteria
(especially hard for laboratory studies
delineation from other disorders) - Moving to validity for specific questions, or
context-based, moves away from notion of
universal truth to notion of utility - Psychiatric diagnosis cannot claim to be valid,
but can claim to be useful in certain contexts
34The Case for Dimensional Classification
- Most disorders lack a zone of rarity
- Genetic and environmental risk cut accross
diagnoses, as do symptoms, and treatments (e.g.
depression anxiety somatisation / psychotic
bipolar) - Would circumvent need for multiple diagnoses, of
unclear validity or utility (treat all?) - Clinicians less pressured to make Procrustean
decisions - forcing diverse presentations into
best fit categories - Less information is lost
- Particularly helpful for trans-cultural work,
where diagnostic categories perceived even more
problematic - Emerging ideas in pharmacotherapy, suggest
medication may target symptoms, not syndromes
response easily measured - Reduction of stigma, through normalisation with
general population, and lack of labelling
35ADHD validity according to Feighner criteria
- Clinical description symptom clusters
- Impairment culture-context specific?
- Laboratory Studies
- Neuroimaging studies (structural functional)
not drug naive (even if unmedicated at time of
imaging) - Functional imaging also tautologous!
- Distinguishes from other conditions, including
effects of maltreatment? - Not well delimited from other disorders, e.g.
paediatric bipolar, emerging emotional unstable
personality disorder (impulsive subtype) and RAD
36ADHD validity according to Feighner criteria
- Does high heritability cannot distinguish
environment from genetic influence? - Twin studies wrongly assume equal environment (DZ
vs MZ)? - Adoption studies methodologically weak often
unblinded, lack adoptee control group (confounds
attachment problems), and do not account for
pre-adoption / pre-natal experience - Individual genes weak effect, non-specific - how
to inherit multiple genes of small effect - DRD4-7 repeat (one of the highest RR 1.45) also
linked with attachment disorganisation, but only
in presence of unresolved maternal loss / trauma - Follow-up highly variable, depending on other
contextual factors
37OUTCOMES
- persistence of symtpoms / impairment
- better prognosis if problem is inattention alone
- poor school achievement
- 32 fail to complete high school
- higher rate of disruptive behaviour disorders
- lack of friends / ?peer problems
- lack of constructive leisure activities
38OUTCOMES
- ?unemployment (67 vs. 40 controls)
- antisocial / personality dysfunction
- substance misuse
- ?criminality (juvenille and adulthood)
- ?road traffic violations and RTAs
- POOR OUTCOMES MEDIATED / MAGNIFIED BY DEVELOPMENT
OF CONDUCT PROBLEMS - seperate but correlated factors in factor
analysis ? seperate dimensions / traits of the
disorder
39Adult ADHD
- Recognition of persistence into adult life
- 15 of those diagnoses still meet full criteria
by age 25 ? prevalence 0.6-1.2 (childhood 4-8) - 65 persistence of some Sx (DSM partial
remission) - criteria may be biased towards younger
developmental stages - Inattention may ? and attention span usually will
usually ? with age - lag behind that of unaffected people and that
necessary / expected for attainment.
40Adult ADHD
- Evolution of Sx
- in pre-school child incessant and demanding
extremes of activity - during school years child may make excess
movements during situations where calm is
expected rather than on every occasion - in adolescence hyperactivity may present as
excessive fidgetiness rather than whole body
movement - in adult life it may be a sustained inner sense
of restlessness.
41Establishing Validity Feigner Criteria
- Robins Guze (1970) / Feighner (1972)
- Clinical description
- Labaratory Studies (i.e. to show biological
dysfunction includes cognitive profile?) - Largely non-specific
- Delimitation from other disorders (c.f. zone of
rarity Kendell 2003) - Few disorders truly seperate
- Follow-up studies (diagnostic stability
response to Rx and outcome) - Highly variable for many disorders
- Family studies
- Disorders overlap
42Producing a Formulation
- A key advantage of formulation over diagnosis is
that it can be used to predict how an individual
might respond in certain situations and to
various psychotherapies or other interventions
43Standard textbook approach
- Socio-demographic summary
- Presentation
- Diagnoses / differentials
- Presumed aetiologies
- Management plan
- Predicted response
- implicitly linked to accuracy of formulation
44DSM-IV Multi-axial evaluation
- I Clinical disorders
- II Personality disorders / learning disability
- III General medical conditions
- IV Psychosocial and environmental problems, inc
- problems related to primary support group
- Educational problems
- Problems with housing / economic / social
environment - V Global assessment of functioning score
45ICD-10 Multi-axial diagnostic formulation
- I clinical disorders (mental and general medical
conditions) include personality developmental
dimensions - II disabilities (in personal care, occupational
functioning, functioning with family, and broader
social functioning / social roles) - III contextual factors (interpersonal and other
psychosocial and environmental problems) - IV quality of life (primarily reflecting
patient's self-perceptions, including spiritual
culturally informed).
46DSM-V Cultural Formulation
- What problems or concerns bring you to the
clinic? what troubles you the most about your
problem? - How would you describe to others not doctors?
Is there a particular term / cultural label? - Why do you think this is happening to you? What
do you think are the particular causes of your - What have your family, friends, and other
people in your life done that may have made your
PROBLEM better/worse? - Is there anything about your background, e.g.
your culture, race, ethnicity, religion or
geographical origin that is causing problems/
helping in your current life situation? - REFLECTING ON CULTURAL IDENTITY AS SOURCE OF
STRENGTH OR OTHERWISE -
47DSM-V Cultural Formulation
- Clarify self-coping for the problem listen for
mental health treatment, medical care, support
groups, folk healing, religious or spiritual
counseling, or other alternative healing. - Barriers to help-seeking, access to care, and
problems engaging in previous treatment. - Is there anything about my own background that
might make it difficult for me to understand or
help you with your PROBLEM? - Establish goals and treatment preferences
48SIRSE framework (from Child Psychiatry, 2nd Ed
Goodman and Scott)
- Symptoms
- Emotional
- Conduct
- Developmental (include attention-activity
levels-impulsivity, speech/language, play, motor,
toilet training, learning literacy / numeracy) - Social relatedness peers, family, authority,
strangers - Impact (how much distress or impairment does it
cause?) - Risks
- Bio-psycho-social
- Predisposing / precipitating / perpetuating /
protective factors - Strengths
- What assets are there to work with?
- Explanatory model
49An additional frameworkRutter, Taylor Hersov
CAAP, Modern Approaches
- Does the child have a psychiatric disorder?
- If there is a disorder does the clinical picture
fit that of a recognized clinical syndrome? - What are the various roots of that disorder in
terms of intrapsychic, family, sociocultural and
biological factors and what are the relative
strengths of each of these root causes in this
particular patient? - What forces are maintaining the problem?
- What forces are facilitating the childs normal
development? - What are the strengths and competencies of the
child and of the family - Untreated what is the likely outcome of the
childs disorder(s)? - Is intervention necessary in this case?
- What types of intervention are most likely to be
effective?
50Should formulation include impact of diagnosis
itself?
- Theoretically we can hold multiple levels of
explanation in mind simultaneously - in practice it can be difficult not to privilege
one level (hard for professionals, even harder
for families?) - different levels may have contradictory
implications for action - Whether intended or not, classification reifies
disorder as a fixed, and real entitiy, located
within the individual - a problem in psychiatry because psychiatric
illness, may be more responsive to changes in
meaning and social context, than physical illness - Impact of diagnosis, and contingent social stigma
on self-identity (which may already be less
developed and robust)
51Case KB
- 8 yr old presenting Sx ADHD / ODD
- Mum victim of CSA
- CP chronology reveals pervasive Hx of neglect,
emotional and physical maltreatment and exposure
to DV - Impact on children minimised by mother
- Significant Speech Language difficulties
- Receptive (ToM) and expressive (internalised
dialogue) - Would meet DSM-IV criteria for ADHD
- Would this be hlepful to give?
52Formulation
- A hook to hang it all on!
- A cook-book / symptom checklist approach to
diagnosis may lead to multiple medications (c.f.
Louis Theroux in America!) and have catastophic
consequences - e.g. Labelling a child who is victim of CSA with
ADHD
53Case HW
- 14 yr m
- Voice hearing (command violence self/other)
involved relationship with voices - Triggered by hearing G/F tell him of physical
abuse - Some prior drug use
- Sees himself as black sheep family withdrawal
longstanding (prognostic / Rx significance) - Peers streetwise, but non-confiding
- Voices reminiscent of protracted bullying
evolves into protector rules of living - Cf. Steiner psychic retreats
54Psychotherapeutic Formulation
- Psychodynamic
- Attachment
- Systemic (include cultural)
55Systemic Formulation
- Cybernetics homeostasis / feedback
- Structural hierarchies / boundaries
- Transitions / family life cycle
- Functional what cause is the Sx serving?
- Beliefs and communication difference and how
this is understood and communicated - Narrative how the problem is talked about is
part of the problem
563 column systemic formulation(Carr 2006)
Contexts Belief systems Behavioural patterns
Family of origin issues Beliefs about change
Social educational professional networks Acknowledged and hidden strengths (subjugated narratives Foucault)
Constitutional factors - Can include medical Disorder, deficit, disability reframing, externalising
57Attachment From Behaviour to Representation
Attachment classification SST / AAI Strange Situation Test (SST) Adult Attachment Interview (AAI)
Secure / Autonomous Cries briefly on separation, happy on reunion, secure base from which to explore Coherent and relevant, appropriate examples, able to acknowledge episodes of distress without overwhelmed
Anxious-ambivalent / preoccupied - enmeshed Distraught on separation, clingy-inconsolable on reunion, cannot explore Bound up in feeling, stories and relationships from the past, winding, overlapping stories, without clear resolution
Anxious-avoidant / dismissing Indifferent on separation and reunion, focused on inanimate object-play overly brief, keen to move onto next question, poverty of description, idealisation without evidence to back up.
Disorganised / unresolved Freezing, oscillation approach-avoidance, anamolous Hard to follow narrative, jumping from past to present, or speaking about past as if present, pronoun confusion
58Hypothesized Parenting Styles
- Secure attuned, able to think about childs
needs separate from their own, flexible but able
to set boundaries - Dismissing harsh, unreflecting, parenting style,
parents unable to attend to childs emotional
needs (or their own), child learns to not feel - Preoccupied parent may be intermittently
available but inconsistently so child learns to
amplify distress to get their needs met - Unresolved frightened or frightening parent
may be linked to parental unresolved grief or
maltreatment
59Family ( cultural) scripts
- Characteristic modes of relating and
communicating distress that run in families - Risk taking
- Dramatic histrionic
- Medicalising / somatising
- Cultural idioms of distress and CBS
- Overdosing (Western shunned in traditional
soc) - Somatisation
- Spirit possession / sorcery / psychotic
behaviour - Symptoms as attachment strategies
- eliciting care
60Psychosomatic Disorders
61Formulations of somatic Sx
- Family / cultural script
- may also be universal characteristic of
mood-anxiety states, selected or de-selected from
awareness by culturally influenced cognitive
processes (automatic somatic-scanning) - Children less enculturated therefore somatic
complaints more common - May include cultural understandings of what
doctors want to hear - Somatisation disorder / Sx much more commonly
reported and Dx by physician interviewer - Children, less educated / illiterate persons, or
those with LD may have more naïve notions of
medicine
62Conscious or unconscious?
- Conscious
- Fictitious (or malingering (sic))
- Induced (by child or parent, or for parent)
- Unconscious
- Dissociative conversion (Freud hysteria)
- Intrapsychic conflict (aggressive / sexual
impulses) - Symbolic resolution (unable to walk fear of own
aggression? Blindness a refusal of desire?) - Naïve notions of neurology (children, uneducated,
LD) - Conforming to perceived expectation of parent /
doctor!
63Unconscious (cont..)
- Traumatic dissociation (Janet)
- Flashbacks, intrusion of visual memory
- Pain, intrusion of somatic memory
- Emotional numbness, emotions split off in
dissociated self - Sensory loss, ongoing pain or memory off split
off in dissociated self - Functional (systemic hypothesis)
- Symptom serving a function within wider family
system e.g. to unite parents, derail conflict - Attachment / scripts / conscious - unconscious
64Case KK
- 17 yr F
- CAMHS 15 depression / anxiety
- Hx domestic violence exposure ?
- Hit and run RTA ? PTSD ? Litigation
- Enmeshed relationship with mother co-dependent
(separation anxiety driven by?) - Ongoing Sx PTSD physical pains
- Ambivalent engagement
- Attachment script / pattern secondary gain
fear of change?
65Disorders of somatisation relevant to childhood /
adolesence
- Somatisation disorder (roots in adolescence)
- Undifferentiated somatoform disorder
- Hypochondriasis
- Body dysmorphic disorder
- Conversion disorder (but dissociation ?normative
in younger children)