McLean Hospital

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McLean Hospital Research Town Meeting
September 28, 2011
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AGENDA

• Research Vision (Rauch)
• Research Administration Process Improvement
  (Paskevich)
• Research Metrics for FY11 (Paskevich)
• IRB Update (Kaufman)
• Email Migration to Partners Exchange Server
• QA / Open Forum (Paskevich)
• Presentation of the Anne M. Cataldo Excellence in
  Mentoring Award (Rauch, Greenfield)
• Reception from 2 pm to 3 pm will follow

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McLean Hospital Research Vision Research Town
Meeting September 28, 2011
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McLean Hospital Charge to Research Vision
Committee

• Establish a scientific and research vision for
  McLean
• Identify how best to realize this vision
• What is needed to
• Sustain current investigators
• Develop junior investigators
• Recruit new investigators
• Assess and facilitate collaborative
  opportunities
• Critical infrastructure needs
• Domains for investment

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McLean Hospital Research Vision Committee

• Developed a research mission statement
• Evaluated McLean research programs strengths,
  weaknesses, opportunities and threats
• Considered a range of institutional research
  metrics, including those related to research
  impact
• Reviewed fiscal context of McLean research
  program
• Examined models of faculty support
• Reviewed faculty recruitment processes
  opportunities

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McLean Hospital Research Mission Statement
The McLean Hospital Research Community is
committed to a full range of basic and clinical
scientific inquiry. We will study the brain
and behavior in both healthy and diseased states
in order to build an improved knowledge base that
can be rapidly and safely translated to improved
patient care. We will promote an environment
that is conducive to discovery, innovation, and
teamwork. Through our research, we will train
the next generation of leaders in psychiatry,
mental health, and neuroscience.
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Research Vision Committee Taskforces Key
Research Domains

• Basic Neuroscience
• Chairs William Carlezon, PhD Joseph Coyle,
  MD
• Clinical Research Clinical Trials, Comparative
  Effectiveness
• Practice-based Evidence Research
• Chairs Shelly Greenfield, MD, MPH Mary
  Zanarini, EdD
• Neuroimaging
• Chairs Scott Lukas, PhD Diego Pizzagalli,
  PhD
• Research Considerations for Divisional Roll-out
  
• Chairs Dost Ongur, MD, PhD Roger Weiss MD

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Research Vision Committee Charge to Taskforces

• Build taskforce with members from within and
  beyond McLean
• Assess domain and evaluate strengths, weaknesses,
  opportunities and threats
• Develop recommendations for action

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Research Vision Committee Timeline

• Research Vision Committee (first convened fall
  2009 )
• Taskforce Work (Spring/Summer 2010)
• Taskforce Reports (Fall 2010)
• Prospective Research Priorities presentation to
  McLean Board Strategic Implementation Oversight
  Committee (Spring 2011)

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Research Vision Committee Highlights of Findings
Actions

• Basic Neuroscience
• Appointed chief of Basic Neuroscience (Joe Coyle)
• Identified promising areas neuroplasticity
  drug discovery
• Focusing on dynamic space assignment to optimize
  use of resources
• Developing plan for expanding and enhancing wet
  lab space
• Addressing needs for increased rodent housing

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Research Vision Committee Highlights of Findings
Actions

• Clinical Research
• - Established Clinical Research Center Planning
  Committee
• - Chairs Jim Hudson Roger Weiss
• - Charge Assess feasibility, evaluate
  benefits/risks develop business plan
• Clinical Research Center (services /
  facility)
• Clinical Research Infrastructure (e.g.,
  research pharmacy)
• Neuroimaging
• - Chairs Scott Lukas Diego Pizzagalli
• - Charge Plan upgrade of McLean Imaging Center
  equipment
• (e.g., replace 1.5T with 3T magnet)

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Research Vision Committee Highlights of Findings
Actions

• Key Recruitments by Division
• Basic Neuroscience established mid-career
  scientist
• - Search identified candidates
• - Recruitment ongoing
• Chief, Division of Depression, Anxiety Stress
• - Search approved
• - Launch anticipated December 2011
• Anticipated future searches TBD
• - Child Adolescent Psychiatry Research
• - Chief Scientific Officer (2013)

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Research Vision CommitteeResearch Metrics

• Research Impact
• Institutional Citations
• Total articles in ISI
• Average citations/year
• Average citations/article
• publications in high impact journals
• Weighted average of journal impact for all
  publications
• Patents
• Filed
• Issued
• Licensed

• Research Activity
• Active Research Funds
• Submitted Applications
• Awarded Applications
• Success Rate
• Career Development Awards
• Collaborations
• Sponsors
• Research Personnel
• Research Financials

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McLean Hospital Scientific Advisory Board

• Charge Meet annually to review McLean portfolio
  advise the President and Board of Trustees
• SAB Membership
• - Chair, Steve Hyman, MD (Harvard)
• - Eric Nestler, MD, PhD (Mt. Sinai)
• - Daniel Pine, MD (NIMH Intramural)
• - Barbara Rothbaum, PhD (Emory)
• - Stephan Heckers, MD (Vanderbilt)
• 1st meeting December 18-19, 2011
• - Focus Building Centers of Excellence
  Innovation

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McLean Hospital Research Vision
Questions Discussion
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Research Administration Process
Improvement (The Project Plan)
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McLean Hospital Research Administration Project
Management

• Research Administration Project Management
• McLean Steering Committee
• Responsibilities meet every other week (or more
  if necessary) to
• Assign tasks and initiatives
• Monitor plan implementation / progress
• Identify obstacles and potential problems
  develop plans to appropriately respond
• Ensure appropriate resources and prioritization
• Provide updates to S. Rauch and P. Markell
• Members
• Peter Paskevich, Chair (Sr. VP for Research
  Administration)
• Raquel Espinosa (Associate Director, Research
  Administration)
• David Lagasse (CFO)
• Catharyn Gildesgame (Director, Strategic
  Implementation)
• Administrative Support
• Kim Roselando (Administrative Manager)

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Project Plan Objectives

• Clarify and differentiate roles and
  responsibilities of McLean PIs, PHS Research
  Management (RM), McL Research Administration (McL
  RA) and other key supporting offices
• Evaluate re-assignment of roles to PHS RM to take
  advantage of centralized expertise and economies
  of scale
• Ensure PIs have appropriate level of support
  inside/outside their departments

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Transferring Roles Responsibilities

• Re-assignment of roles to PHS Research Management
  to take advantage of centralized expertise and
  economies of scale
• Transfer of Functions
• PCRO (Partners Clinical Research Office)
• Industry-sponsored clinical research
• Tasks Drafting and negotiating agreements.
  Projected Volume 10-15 studies/year
• RVL (Research Ventures Licensing)
• Industry-sponsored pre-clinical research
• Tasks Reviewing and negotiating agreements.
  Projected Volume 5 - 10/year
• RVL (Research Ventures Licensing)
• Tasks Intellectual Property Protection,
  Technology Transfer, MTAs, CDAs, invoicing,
  tracking and distributing milestone and royalty
  payments. Projected Volume 10 new disclosures
  /year
• GC (Grants Contracts)
• Tasks Complex Subcontracts . Projected Volume
  10 /year

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Why this is important and how it will benefit you

• Increased efficiency by leveraging PHS Research
  Management centralized expertise and economies of
  scale
• Improved customer service and efficiency by
  consolidating functions in specialized offices
• Increased accountability through clarification of
  roles and responsibilities, reporting
  relationships
• Increased support for PIs provided by
  knowledgeable, effective and efficient key
  contacts per activity
• Competitive budget negotiations with industry
  sponsors
• Licensing and Marketing of inventions

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• Research Metrics

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Research Metrics
Division / Center Name Number of New Federal Awards FY11 YTD Total Award
Alcohol Drug Abuse Division, Director Roger Weiss, MD 3 1,168,851
Basic Neuroscience Division, Director Joseph Coyle, MD 6 4,490,580
NeuroImaging Center, Directors Scott Lukas, PhD Diego A. Pizzagalli, PhD 3 1,118,611
Psychotic Disorders Division, Director Dost Ongur, MD, PhD 4 506,330
Divisions to be Established 2 324,647
TOTALS 18 7,609,019
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Research Expenses
FY02 FY 10 Actuals, FY11 Projected (000)
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McLean Hospital IRB Update Research Town
Meeting September 28, 2011
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McLean Hospital

• IRB Update
• AAHRPP Accreditation
• Electronic IRB (eIRB)
• IRB Staff Changes

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draft 9-20-2011
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• Email Migration to Partners Exchange Server

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Email Migration to Partners Email

• Timeline
• Targeted for early calendar year 2012
• Dependency on PHS readiness of new platform
• Timeline assessed weekly with Exchange Team
• Provide a 4 week buffer for "transition"

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Benefits of Migrating to Partners Email

• Continue with _at_mclean.harvard.edu
• also receive mail via partners.org, mclean.org
• Ability to set any as primary send/receive
• Access to the Partners Global Address book
• all users across PHS in exchange, auto lookup
• Shared Calendar functionality
• Integrated Calendar, email, notes, tasks, etc
• Email access outside the hospital via robust
  website
• Integration with smart phones (blackberry,
  iPhone/iPad)
• Ability to delegate to administrative managers
• Out of office messages to both internal and
  external recipients
• 24x7x365 support

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What Researchers Have To Do

• On the "Transition" day
• Configure your email clients to send/receive new
  email through your partners accounts
• Begin transfer of mail out of your existing
  McLean Email account. Completed before McLean
  Email server is shutdown (Exact Date TBD)
• During transition period you will not loose
  access to email
• Step-by-Step documentation has been developed and
  posted to the RIS site
• McLean RIS/ERIS is on site and ready to assist as
  needed to configure clients, folders, etc

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Managing your Mailbox Size

• Empty trash regularly
• Use http//transfer.partners.org to send large
  attachments
• Archive mail to local folders
• Sort Inbox by size and relocate the larger emails

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Mail Box Storage

• Depending upon current usage, 100 or 300 MB to
  start and you can request up to 1 GB
• The request process is currently under
  development
• Larger mailboxes are not free
• Low cost associated with it which will be
  absorbed by McLean IS
• Working on a price structure

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McLean Hospital
QA / Open Forum
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• Presentation of the
• Anne M. Cataldo
• Excellence in Mentoring Award

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