National Pediatric Critical Care Collaborative Research Network

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National Pediatric Critical Care Collaborative
Research Network

• Carol E. Nicholson, MD
• NIH/NICHD/NCMRR
• Pediatric Critical Care and Rehabilitation
  Research

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Vision

• a collaborative pediatric critical care research
  network of interactive clinical and translational
  science research groups.

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Purpose and Vision -I

• promote the efficient comparison of novel
  critical care treatment methods and management
  strategies of potential benefit for children and
  who are critically ill and/or injured.

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Purpose and Vision-II

• Fund the infrastructure required for a network of
  six core clinical centers to perform clinical
  trials, translational and descriptive research
  in pediatric critical illness and injury

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Purpose and Vision- III

• Seek descriptive and translational science in the
  pathophysiology of critical illness in children,
  especially

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In survivors of childhood critical illness.

• Linking outcomes (functional and developmental)
  to critical illness and its management
• Minimizing the effect on siblings and families of
  devastating childhood illness
• Reintegration of child into home, school, family
  as the ultimate goal of critical care practice

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In the subspecialty.

• Understanding the pathophysiology of critical
  illness, particularly multiple organ system
  failure (MOSF)
• Evaluating practice our own, other specialties
  caring for children.
• Finding adequate outcome measures of pediatric
  critical care practice

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How will the Network be Constituted ?

• Up to six core clinical centers
• Data Coordinating Center
• NICHD assistance
• Project Officer
• Project Scientist
• Steering Committee
• Chairman

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The Money.

• Total amount of set-aside 5M (years 2-5)
• 1M Data Coordinating Center (separate RFA)
• To fund core clinical centers 4M

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How much each, for what?

• Infrastructure operating costs
• Each center direct costs
• First year 100,000
• Years 2-5 450,000
• Full time research nurse
• 10-15 PI time
• Half time data entry /administrative staff

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To qualify, these centers MUST..

• HAVE STRONG FOLLOWUP of CHILDREN who have
  devastating illness or injury
• Your longer term care colleagues are looking for
  you.get involved!

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Governance of the Network

• Steering Committee
• consists of
• PIs
• NICHD Project Scientist
• DCC PI
• Chairman (NICHD appointed)

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Choosing a Funding Mechanism
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What is a Cooperative Agreement?

• Substantial NICHD scientific and/or programmatic
  involvement with the recipient is anticipated.
• An award instrument establishing an "assistance
  relationship between the NIH institutes (NICHD)
  and a recipient.

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To Clarify, a bit.

• NICHDs purpose in this relationship
• to support and/or stimulate the recipient's
  activity by involvement in and otherwise
  facilitating the activity in a "partner" role
• avoid a dominant role, direction, or prime
  responsibility.

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How will applicants be evaluated?

• Three areas
• Characteristics of the Proposed Center
• Principal Investigator and Identified Research
  Nurse
• Proposed Science

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Review of Applications

• CRITERIA include
• Significance
• Approach
• Investigator
• Environment
• Additional Review Criteria in RFA

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The review will be by a SEP

• Special Emphasis Panel, convened by NICHD just
  for this purpose.
• The Scientific Review Administrator will select
  and invite the review committee members
• Not all members of the review group will be
  intensivists

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Looking at the three aspects of the application
to be submitted

• A paradigm preparing to board the train
• Is it the right train for you?
• Dont get on the train to New York if you want to
  get to Kansas City

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Characteristics of the Center

• A table of the characteristics of your pediatric
  critical care service
• of patients in each category
• Institutional personnel and services

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Principal Investigator and Research Nurse

• Evidence of commitment to research
• Evidence of commitment to collaboration
• Research Nurse must be identified at the time of
  application
• Each Principal Investigator must be a fully
  qualified pediatric intensivist.

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Dont let the timing bother you.

• Publication April, 2004
• Applications due August 9, 2004
• Anticipated funding Spring, 2005

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..Summer, 2004

• Due date August, 2004
• start now, so that summer is peaceful, and the
  Network applications begin to

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Develop with passion and precision
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help one another get started
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Things to do first!

• Identify research nurse and princicpal
  investigator
• Get buy-in at your institution.is this the right
  train for you? Ask the neos
• Identify the science you will propose and begin
  the SEVEN STEPSmake your notebook
• You will need to know ages and diagnostic
  categories of PICU patients..

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California Dreamin