Ionized Water An Alternative Therapy for Cellular Stress

1
Ionized WaterAn Alternative Therapy for Cellular
Stress

• Tim McKnight, MD, MS, FAAFP
• May 15, 2011
• Palm Desert, California

2
My background
3
Fit For Life

• Healthy Community Outreach Program
• Rural Health Services Outreach Grant
• Department of Health Human Services

4
The American Wellness Crisis

• Obesity
• Heart Disease
• Hypertension
• Elevated Lipids
• Cancer
• Diabetes
• Acid Reflux
• Gallstones
• Arthritis
• Sleep Apnea

• Substance Abuse
• Depression
• Anxiety
• ADHD
• Back Pain
• Irritable Bowel Syndrome
• Autoimmune disease
• Rheumatoid arthritis
• Inflammatory Bowel
• Thyroiditis

5
Leading Causes of Death

• Heart Disease710,760
• Cancer553,091
• Medical Care.225,400
• Stroke.167,661
• COPD.122,009
• Accidents.97,900
• Diabetes...69,301
• Influenza/Pneumonia.65,313
• Alzheimers Disease..49,558

Anderson RN. Deaths leading causes for 2000.
National Vital Statistics Reports 50(16), 2002
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Death by Health Care1

• Medical Errors.7,4002
• Unnecessary Surgery..12,0003
• Other Preventable Hospital Errors.20,000
• Hospital Borne Infections.80,000
• Adverse Drug Effects ....106,0004

1- Starfield B. Is U.S. health really the best
in the world? JAMA 284 (2000) 483-85 2-
Phillips D, et al Increase in U.S.
medication-error death between 1983-1993.
Lancet 351 (1998) 643-644 3- Leape L.
Unnecessary surgery. Ann. Rev. Publ. Health 13
(1992) 363-383 4- lazorou J. Pomeranz B,
Corey PN. Incidence of adverse drug
reaction in hospitalized patients. JAMA 279
(1998)1200-1205
7
Prescription Practices among American Doctors

• Number of drugs ordered or provided 2.0
  billion
• Average number of drugs ordered or provided per
  visit 2.1
• Percent of visits involving drug therapy 71
• Most frequently prescribed therapeutic class
  Antidepressants

Source U.S. DEPARTMENT OF HEALTH HUMAN
SERVICESCenters for Disease Control and
Prevention
8
Big Rx ales winners in 2002
v 1. Lipitor (cholesterol-lowering) 5.58
billion (up 18)v 2. Zocor (cholesterol-lowering)
4.069 billion (up 18)v 3. Prevacid (ulcers,
reflux) 3.894 billion (up 4)v 4. Prilosec
(ulcers, reflux) 3.341 billion (? 22 after
going generic in 2002) 5. Procrit gt2
billion, exact numbers N/Av 6. Zyprexa
(neuroleptic) 2.716 billion (up 15) v 7.
Paxil (SSRI antidepressant) 2.509 billion (up
13)v 8. Zoloft (SSRI antidepressant) 2.445
billion (up 13) 9. Epogen gt2 billion, exact
numbers N/Av 10. Celebrex (anti-inflammatory)
2.380 billion (up 5.3)v 11. Nexium (ulcers,
reflux) 2.000 billion (new drug) 12.
Neurontin (seizures, pain) 2.000 billionv 13.
Norvasc (antihypertensive) 1.814 billion (up
5)
9
Per Capita Total Current Health Care
Expenditures, U.S. and Selected Countries, 2006
US Ranking 1 Responsiveness 1
Expenditures 37 Performance 72 Health WHO
data (n191 Countries)
Source Organization for Economic Co-operation
and Development. OECD Health Data 2008, from the
Source OECD Internet subscription database
updated October 2008.
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The Changing American Diet

• 1900 industrialization/urbanization local
  grocers Challenge How to extend the shelf-life
  of foods?
• 1940s nutritional deficiencies ? Enrichment
  Act
• 1950s Animal proteins (meat milk) promoted
• 1960s Growth of fast food chains diet pills
  emerge
• 1970s Food Pyramid developed (anti-fat
  campaign)
• HFCS enters food supply
• Trans (hydrogenated fats) enter the
  food supply
• 1980s Microwave ovens loss of family dinner
  hour
• 1990s Super-sizes
• 2000s ?

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Diet and CancerIncrease Risk Decrease
Risk

• Meats
• Dairy
• Total Fat
• Saturated Fat
• Refined Sugar
• Total Calories
• Alcohol

• Fish
• Whole grains
• Legumes
• Cabbages
• Broccoli, cauliflower, cabbage
• Vegetables
• Nuts
• Fruits

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12
Preventing Heart Disease

• High Blood Pressure diet, exercise, ideal
  weight
• Diabetes diet, exercise, ideal weight
• Elevated Cholesterol - diet, exercise, ideal
  weight
• Smoking STOP!
• Family history - ?

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13
Percent of Avoidable Chronic Diseases
91
82
71
70
Source The Culprit The Cure, p 5 Steven G.
Aldana, PhD. Maple Mountain Press, 2005. NEJM
2000. July 6343(1)16-22, Cancer Causes
Control 2000. August11(7)579-88, NEJM
2001.Sept 13345(11)790-7
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Sometimes in our quest for wellness, we fail to
see that WE are the solution!
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A TruthThe body is designed to heal itself

• Digestive System absorbs nutrients
• Cardio Pulmonary System circulates nutrients
• Renal System removes waste products
• Nervous System communication center
• Endocrine System relay system
• Immune System protects against cancer/microbes

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The Miraculous Cell

• Each cell has its own unique machinery to repair
  heal itself.
• MILLIONS of DNA repairs occur each second.
• Every day 10,000 free radicals attack the DNA of
  EVERY cell
• Each cell contains organs
• A lesson of harmony, balance, order
  interdependence
• Cells sense and respond to their environment
• Redox potentials (ORP) signal imbalance (stress)
  and initiates cellular repair
• Cells communicate with and warn each other
• All proteins, lipids, nucleic acid interact with
  water

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Lessons from Nature

• Stress Recovery
• We are designed to adapt to short-term bursts of
  stress, NOT chronic!
• Day and Night
• Summer and Winter
• Muscular stress Recovery
• Stress Recovery in Healing?

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Our health is primarily threatened by

• STRESS

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STRESS

• An imbalance of forces

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Healing Wellness
Balance (Harmony with natural law)
Stress
Imbalance (disharmony with natural law)
Dysfunction Disease
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Oxidative Stress

• THE mechanism of disease AND aging

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Oxidative stress via Free
Radicals

• Unpaired, negatively charged particles
• Move at very high speeds
• Steal electrons from adjacent molecules, making
  them unstable and reactive
• Like sparks from a fire (lifespan is 1 trillionth
  of a second)
• Free Radicals were proposed as the root cause of
  AGING in1956
• (Harman D. Aging Theory based on free
  radical and radiation chemistry.
• J Gerontology 11298-300, 1956.)

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Sources of Free Radicals

• Normal respiration metabolism
• Exercise
• Microbes viruses, bacteria, parasites, fungi
• Air pollutants, pesticides, herbicides, tobacco
• Radiation X-rays, UV light microwaves
• Drugs (alcohol, medications, etc)
• Dietary
• Fats (esp. hydrogenated fats, rancid fats, fried
  fats, or charred fats)
• High sugar diets
• Stress (cortisol)
• Injury/trauma

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Free RadicalsReactive Oxygen Species (ROS)

• Superoxide anion radical (O2 . -)
• Singlet Oxygen (1O2)
• Hydroxyl radicals (OH-)
• Hydrogen Peroxide (H2O2)

ROS have a positive ORP !
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Free Radicalsthe good, the bad, the ugly

• Immune processes generate free radicals to
  destroy microbial invasion
• A byproduct of ATP synthesis and cellular
  detoxification
• Oral (food/medications) and air-borne free
  radical exposures can be significant
• ONE puff of cigarette smoke contains how many
  free radicals?
• Answer 100,000,000,000,000,000 !!!

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Ionizing radiation
Exercise
STRESS!!!
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Free radicals oxidative stress
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Free Radicals and Oxidative Structural Damage

• Damages collagen cross-links ? wrinkles
• Damages elastin in arteries ? hypertension
• Damages intimal lining ? atherosclerosis (hs-CRP)
• Damage to DNA/RNA ? mutations, inefficient repair
  processes and cancer
• Damage to Insulin Receptor ? diabetes

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Natures PrescriptionagainstFree Radical Damage
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Cellular Anti-oxidants

• Cell membrane protection
• Vitamin E and beta-carotene
• Extracellular fluid protection
• Vitamin C and Glutathione
• Intracellular protection
• Glutathione, Vitamin C, Selenium
• CoQ10 (mitochondria)
• Melatonin (protects brain nDNA and mDNA)

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Cellular Anti-oxidants

• Vitamins A (ß-carotene), E, C
• Selenium, Zinc, Manganese, Copper, Iron
• Glutathione (GSH)
• a-Lipoic Acid
• N-acetylcysteine

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Anti-oxidants regenerate each other

• Vit C Vit E Selenium ? ß-carotene
• CoQ10 in mitochondria ? Vit E
• a-Lipoic Acid proanthocyanidines ? Vit C

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USDA data on foods with high ORAC scores USDA data on foods with high ORAC scores USDA data on foods with high ORAC scores
Food Serving size Oxygen Radical Absorbance Capacity per serving
Small Red Bean ½ cup dried beans 13,727
Wild blueberry 1 cup 13,427
Red kidney bean ½ cup dried beans 13,259
Pinto bean ½ cup 11,864
Blueberry 1 cup (cultivated berries) 9,019
Cranberry 1 cup (whole berries) 8,983
Artichoke hearts 1 cup, cooked 7,904
Blackberry 1 cup (cultivated berries) 7,701
Prune ½ cup 7,291
Raspberry 1 cup 6,058
Strawberry 1 cup 5,938
Red Delicious apple 1 apple 5,900
Granny Smith apple 1 apple 5,381
Pecan 1 oz 5,095
Sweet cherry 1 cup 4,873
Black plum 1 plum 4,844
With nearly all vegetables, conventional boiling
reduces the ORAC value significantly, while
steaming retains more of the antioxidants
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Anti-oxidant Supplements(Anti-Free Radicals)
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Anti-oxidants

• Herbs
• Turmeric, Ginko
• Supplements
• CoQ10, DHEA-S, Grape Seed Extract, Lipoic Acid,
  Lycopene
• Enzyme Systems (require adequate Se, Cu, Mn, Zn,
  Fe)
• Catalase
• Super Oxide Dismutase (SOD)
• Glutathione Peroxidase

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Acidic Stress

• A precursor to Oxidative Stress

40
Acids Loads

• Blood pH range is 7.35 7.45
• Acid is a byproduct of cell metabolism and
  repair, yielding a net gain in acid load
• i.e. Urine pH is 6.0 (not 7.4) due to acid
  excretion
• The body must maintain relative neutrality by
  buffering systems
• 3 systems suggest the importance of acid-base
  balance (fluid buffers, kidneys, lungs)
  

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Acids, Bases, Buffers Balance

• Lungs
• The primary buffer of blood pH
• 1-2 times as potent as chemical buffers (fast)
• Kidneys
• The secondary buffer of blood pH (slow)
• urine pH6.0
• Chemical Buffers
• Intracellular
• Proteins provides ¾ of all chemical buffering
• Bone via Calcium carbonate and Calcium phosphate
• Extracellular
• Fluids Buffers
• Sodium Bicarbonate
• Sodium Phosphate

Guyton A., Textbook of Medical Physiology8th Ed,
1991, WB Saunders Co.
42
pH of various body fluids

• Inside Cell 7.2-7.4
• Blood 7.4
• Urine 6.0
• Stomach 2.5
• Intestines 8.0
• Skin 4.5-6.0
• Saliva 6.0-7.4
• Vagina 3.8-4.5

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Acidic Loads ?
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Chronic Acidic States

• Acid Reflux
• Cancer
• Gout
• Kidney Stones
• Osteoporosis
• Dental Disease

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Alkaline Foods Spinach Broccoli Olive
Oil Apples Almonds Carrots Cabbage Acid
Foods Coffee White Bread Beef Pastries Pasta Dairy
products Soft Drinks
D
D
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Alternative Therapies, Jul/Aug 2007, Vol. 13, No.
4, p 62-65.
Over time, ingestion of a high dietary acid load
can progress to a chronic low-grade level of
metabolic acidosis. Increasing evidence
suggests that such persisting, allbeit low-grade,
acidosis, and the relentless operation of
responding homeostatic mechanisms, result in
numerous injurious effects on the body including
dissolution of bone, muscle wasting, kidney stone
formation, and damage to the kidney.
47
Acid or Alkaline?

• Otto Warburg
• Nobel Peace Prize 1931

• Discovered The Cause of Cancer

• Cancer thrives in an acidic, oxygen-depleted
  environment
• Excess sugars processed flour, dairy, meats,
  soft drinks, STRESS
• Inactivity ? oxygen depletion
• Cancer cannot grow in an alkaline, oxygen-rich
  environment

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Dehydration Stress
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Dehydration

• We are 75 water
• We are one big biochemical reaction
• Water is the ideal solvent
• Thirst mechanism activated after we are 5
  dehydrated
• We are dehydrated in the morning
• Caffeine is the most common diuretic on the
  planet
• Youngsters dehydrate faster than adults

50
Dehydration States

• Physical activity
• Sun/heat exposure
• Aging
• Sleep
• Constipation
• Kidney stones
• Diuretic use

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Evidence for Micro-clustering

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Micro-clustered Water water molecules clump
together in clusters (measured by Nuclear
Magnetic Resonance)

• Alkaline Reduced Water has Low NMR
• Lower Resonance (vibration) allows for closer
  association between molecules
• This renders the water tighter in structure,
  allowing micro-clustering of molecules
• hence water better at penetrating and hydrating
• The water also has a low surface tension
  (measured in dynes)

54
Nuclear Magnetic Resonance Technology (NMR)
measures water cluster size

• The lower the NMR reading, the smaller the
  clusters
• Bottled mineral water 90-100 Hz.
• Normal tap water 128 Hz
• Reverse Osmosis 128 Hz
• Distilled water 128 Hz
• Hexagonal, Ionized water 42.3 Hz

National Tsing Hua University Report No. GMC
0203001 dated 28th March 2002
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Chemistry of Ionized Water
Alkaline (OH-) Acid (H)
(-ORP) (ORP) Split
Water
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Oxidation-Reduction Potential (ORP)

• Measured in mV
• Positive values are oxidizing (act like free
  radicals)
• Negative values are reducing (anti-oxidizing)
• Active hydrogen (H2) is a hydrogen atom that has
  an additional electron in its outer shell
• This extra electron is able to donate it to other
  compounds, acting as an anti-oxidant
• Active hydrogen (H2) has an incredibly low redox
  reading (-400 to -800 mV)

57
Evidence for Internal Treatment
58
BIOCHEMICAL AND BIOPHYSICAL RESEARCH
COMMUNICATIONS 234, 269274 (1997) ARTICLE NO.
RC976622 ElectrolyzedReduced Water Scavenges
Active Oxygen Species and Protects DNA from
Oxidative Damage Sanetaka Shirahata,1 Shigeru
Kabayama, Mariko Nakano, Takumi Miura, Kenichi
Kusumoto, Miho Gotoh, Hidemitsu Hayashi,
Kazumichi Otsubo, Shinkatsu Morisawa, and
Yoshinori Katakura Institute of Cellular
Regulation Technology, Graduate School of Genetic
Resources Technology, Kyushu University,
6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-81,
Japan Water Institute, Nisshin Building 9F,
2-5-10 Shinjuku, Tokyo 160, Japan and Nihon
Trim Co. Ltd., Meiji Seimei Jusou Building 6F,
1-2-13 Shinkitano, Yodogawa-ku, Osaka 532,
Japan Received March 21, 1997 Active oxygen
species or free radicals are considered to cause
extensive oxidative damage to biological
macromolecules, which brings about a variety of
diseases as well as aging. The ideal scavenger
for active oxygen should be active hydrogen.
Active hydrogen can be produced in reduced
water near the cathode during electrolysis of
water. Reduced water exhibits high pH, low
dissolved oxygen (DO), extremely high dissolved
molecular hydrogen (DH), and extremely negative
redox potential (RP) values. Strongly
electrolyzedreduced water, as well as ascorbic
acid, (/)-catechin and tannic acid, completely
scavenged O2 produced by the hypoxanthine-xanthin
e oxidase (HX-XOD) system in sodium phosphate
buffer (pH 7.0). Vol. 234, No. 1, 1997
BIOCHEMICAL AND BIOPHYSICAL
ERW with high pH and significant negative ORP
was shown to have SOD-like activity and
catalase-like activity, and thus, scavenge active
oxygen species and protect DNA from damage by
free radicals in vivo
59
BIOCHEMICAL AND BIOPHYSICAL RESEARCH
COMMUNICATIONS 234, 269274 (1997) ARTICLE NO.
RC976622 ElectrolyzedReduced Water Scavenges
Active Oxygen Species and Protects DNA from
Oxidative Damage Sanetaka Shirahata,1 Shigeru
Kabayama, Mariko Nakano, Takumi Miura, Kenichi
Kusumoto, Miho Gotoh, Hidemitsu Hayashi,
Kazumichi Otsubo, Shinkatsu Morisawa, and
Yoshinori Katakura Institute of Cellular
Regulation Technology, Graduate School of Genetic
Resources Technology, Kyushu University,
6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-81,
Japan Water Institute, Nisshin Building 9F,
2-5-10 Shinjuku, Tokyo 160, Japan and Nihon
Trim Co. Ltd., Meiji Seimei Jusou Building 6F,
1-2-13 Shinkitano, Yodogawa-ku, Osaka 532,
Japan Received March 21, 1997 Active oxygen
species or free radicals are considered to cause
extensive oxidative damage to biological
macromolecules, which brings about a variety of
diseases as well as aging. The ideal scavenger
for active oxygen should be active hydrogen.
Active hydrogen can be produced in reduced
water near the cathode during electrolysis of
water. Reduced water exhibits high pH, low
dissolved oxygen (DO), extremely high dissolved
molecular hydrogen (DH), and extremely negative
redox potential (RP) values. Strongly
electrolyzedreduced water, as well as ascorbic
acid, (/)-catechin and tannic acid, completely
scavenged O2 produced by the hypoxanthine-xanthin
e oxidase (HX-XOD) system in sodium phosphate
buffer (pH 7.0). Vol. 234, No. 1, 1997
BIOCHEMICAL AND BIOPHYSICAL
BIOCHEMICAL AND BIOPHYSICAL RESEARCH
COMMUNICATIONS 234, 269274 (1997) ARTICLE NO.
RC976622 ElectrolyzedReduced Water Scavenges
Active Oxygen Species and Protects DNA from
Oxidative Damage Sanetaka Shirahata,1 Shigeru
Kabayama, Mariko Nakano, Takumi Miura, Kenichi
Kusumoto, Miho Gotoh, Hidemitsu Hayashi,
Kazumichi Otsubo, Shinkatsu Morisawa, and
Yoshinori Katakura Institute of Cellular
Regulation Technology, Graduate School of Genetic
Resources Technology, Kyushu University,
6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-81,
Japan Water Institute, Nisshin Building 9F,
2-5-10 Shinjuku, Tokyo 160, Japan and Nihon
Trim Co. Ltd., Meiji Seimei Jusou Building 6F,
1-2-13 Shinkitano, Yodogawa-ku, Osaka 532,
Japan Received March 21, 1997 Active oxygen
species or free radicals are considered to cause
extensive oxidative damage to biological
macromolecules, which brings about a variety of
diseases as well as aging. The ideal scavenger
for active oxygen should be active hydrogen.
Active hydrogen can be produced in reduced
water near the cathode during electrolysis of
water. Reduced water exhibits high pH, low
dissolved oxygen (DO), extremely high dissolved
molecular hydrogen (DH), and extremely negative
redox potential (RP) values. Strongly
electrolyzedreduced water, as well as ascorbic
acid, (/)-catechin and tannic acid, completely
scavenged O2 produced by the hypoxanthine-xanthin
e oxidase (HX-XOD) system in sodium phosphate
buffer (pH 7.0). Vol. 234, No. 1, 1997
BIOCHEMICAL AND BIOPHYSICAL
Anticancer Effect of Alkaline Reduced
Water Kyu-Jae LEE1,2, Seung-Kyu PARK1,2,
Jae-Won KIM1, Gwang-Young KIM1, Young-Suk RYANG5,
Geun-Ha KIM 1, Hyun-Cheol CHO3, Soo-Kie KIM2,3,
and Hyun-Won KIM2,4 1 Dept. of Parasitology, 2
Institute of Basic Medical Sciences, 3 Dept. of
Microbiology, 4 Dept. of Biochemistry, Wonju
College of Medicine, Yonsei Univ. ( Wonju ,
Korea) 5Dept. of Biomedical Laboratory Science
and Institute of Health Science, College of
Health Science, Yonsei Univ. ( Wonju ,
Korea) Abstract Certain minerals can produce
alkaline reduced water with high pH and low
oxidation-reduction potential (ORP) when
dissolved in water. Alkaline reduced water (ARW)
showed significant anticancer effect. When B16
melanoma cells were inoculated subcutaneously and
intra-peritoneally, C56BL/6 mice fed with ARW
showed tumor growth delay and the survival span
was significantly lengthened. ARW also showed the
inhibition of metastasis by reducing the numbers
of B16 melanoma colonies when injected through
tail vein. The amount of reactive oxygen species
(ROS) was very reduced when fed with ARW except
for spleen, which is a major organ for immunity.
Even for normal mice, ARW intake invoked systemic
cytokines, such as, Th1 (IFN-g, IL-12) and Th2
(IL-4, IL-5), suggesting strong immuno-modulation
effect. Both ROS scavenging effect and
immuno-modulation effect might be responsible for
anticancer effect of alkaline reduced
water. Keyword alkaline reduced water,
anticancer effect, antioxidant,
immuno-modulation Introduction Reactive oxygen
species (ROS) or free radicals are one of the
major offenders to render oxidative damage to
biological macromolecules. These unstable ROS are
known to cause or aggravate a variety of
incurable diseases such as cancer, cardiovascular
diseases, neurodegenerative diseases as well as
aging 1, 2 The cellular radical-scavengers such
as superoxide dismutase, catalase, glutathione
peroxidase are natural defense system against
ROS. External source of anti-oxidative protection
include antioxidant vitamins C and E, carotene
and carotenoids as well as minerals such as
selenium and zinc. Great efforts have been made
in an attempt to find safe and potent natural
antioxidants.
60
Electrolyzed-reduced water scavenges active
oxygen species and protects DNA from oxidative
damage. Biochem Biophys Res Commun. 1997 May
8234(1)269-74.Shirahata S, Kabayama S, Nakano
M, Miura T, Kusumoto K, Gotoh M, Hayashi H,
Otsubo K, Morisawa S, Katakura Y. Institute of
Cellular Regulation Technology, Graduate School
of Genetic Resources Technology, Kyushu
University, Fukuoka, Japan. sirahata_at_grt.kyushu-u.
ac.jp Active oxygen species or free radicals
are considered to cause extensive oxidative
damage to biological macromolecules, which brings
about a variety of diseases as well as aging. The
ideal scavenger for active oxygen should be
'active hydrogen'. 'Active hydrogen' can be
produced in reduced water near the cathode during
electrolysis of water. Reduced water exhibits
high pH, low dissolved oxygen (DO), extremely
high dissolved molecular hydrogen (DH), and
extremely negative redox potential (RP) values.
Strongly electrolyzed-reduced water, as well as
ascorbic acid, ()-catechin and tannic acid,
completely scavenged O.-2 produced by the
hypoxanthine-xanthine oxidase (HX-XOD) system in
sodium phosphate buffer (pH 7.0). The superoxide
dismutase (SOD)-like activity of reduced water is
stable at 4 degrees C for over a month and was
not lost even after neutralization, repeated
freezing and melting, deflation with sonication,
vigorous mixing, boiling, repeated filtration, or
closed autoclaving, but was lost by opened
autoclaving or by closed autoclaving in the
presence of tungsten trioxide which efficiently
adsorbs active atomic hydrogen. Water bubbled
with hydrogen gas exhibited low DO, extremely
high DH and extremely low RP values, as does
reduced water, but it has no SOD-like activity.
These results suggest that the SOD-like activity
of reduced water is not due to the dissolved
molecular hydrogen but due to the dissolved
atomic hydrogen (active hydrogen). Although SOD
accumulated H2O2 when added to the HX-XOD system,
reduced water decreased the amount of H2O2
produced by XOD. Reduced water, as well as
catalase and ascorbic acid, could directly
scavenge H2O2. Reduced water suppresses
single-strand breakage of DNA by active oxygen
species produced by the Cu(II)-catalyzed
oxidation of ascorbic acid in a dose-dependent
manner, suggesting that reduced water can
scavenge not only O2.- and H2O2, but also 1O2 and
.OH. PMID 9169001
61
Life Science. 2006 Nov 1079(24)2288-92. Epub
2006 Aug 2. Anti-diabetic effects of electrolyzed
reduced water in streptozotocin-induced and
genetic diabetic mice. Kim MJ, Kim HK. Department
of Obesity management, Graduate School of Obesity
Science, Dongduk Women's University, 23-1
Wolkgukdong, Seoul, 136-714, South Korea.
mijakim_at_dongduk.ac.kr Oxidative stress is
produced under diabetic conditions and is likely
involved in progression of pancreatic beta-cell
dysfunction found in diabetes. Both an increase
in reactive oxygen free radical species (ROS) and
a decrease in the antioxidant defense mechanism
lead to the increase in oxidative stress in
diabetes. Electrolyzed reduced water (ERW) with
ROS scavenging ability may have a potential
effect on diabetic animals, a model for high
oxidative stress. Therefore, the present study
examined the possible anti-diabetic effect of ERW
in two different diabetic animal models. The
genetically diabetic mouse strain C57BL/6J-db/db
(db/db) and streptozotocin (STZ)-induced diabetic
mouse were used as insulin deficient type 1 and
insulin resistant type 2 animal model,
respectively. ERW, provided as a drinking water,
significantly reduced the blood glucose
concentration and improved glucose tolerance in
both animal models. However, ERW fail to affect
blood insulin levels in STZ-diabetic mice whereas
blood insulin level was markedly increased in
genetically diabetic db/db mice. This improved
blood glucose control could result from enhanced
insulin sensitivity, as well as increased insulin
release. The present data suggest that ERW may
function as an orally effective anti-diabetic
agent and merit further studies on its precise
mechanism.PMID 16945392
62
Biol Pharm Bull. 2007 Feb30(2)234-6. Preservati
ve effect of electrolyzed reduced water on
pancreatic beta-cell mass in diabetic db/db
mice. Kim MJ, Jung KH, Uhm YK, Leem KH, Kim
HK. Department of Obesity Management, Graduate
School of Obesity Science, Dongduk Women's
University, Seoul, South Korea.
mijakim_at_dongduck.ac.jp Oxidative stress is
produced under diabetic conditions and involved
in progression of pancreatic beta-cell
dysfunction. Both an increase in reactive oxygen
free radical species (ROS) and a decrease in the
antioxidant defense mechanism lead to the
increase in oxidative stress in diabetes.
Electrolyzed reduced water (ERW) with ROS
scavenging ability may have a potential effect on
diabetic animals, a model for high oxidative
stress. Therefore, the present study examined the
possible anti-diabetic effect of ERW in
genetically diabetic mouse strain C57BL/6J-db/db
(db/db). ERW with ROS scavenging ability reduced
the blood glucose concentration, increased blood
insulin level, improved glucose tolerance and
preserved beta-cell mass in db/db mice. The
present data suggest that ERW may protect
beta-cell damage and would be useful for
anti-diabetic agent. PMID 17268057 PubMed -
indexed for MEDLINE
Ionized water neutralized the harmful effects of
free radicals on the pancreas AND improved blood
sugar insulin action
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Ther Apher Dial. 2009 Jun13(3)220-4. Ionized
alkaline water new strategy for management of
metabolic acidosis in experimental
animals. Abol-Enein H, Gheith OA, Barakat N,
Nour E, Sharaf AE. Department of Urology, El
Mansoura Urology and Nephrology Center, Mansoura
University, 72 Gomhoria Street, Mansoura,
Egypt. Abstract Metabolic acidosis can occur as
a result of either the accumulation of endogenous
acids or loss of bicarbonate from the
gastrointestinal tract or the kidney, which
represent common causes of metabolic acidosis.
The appropriate treatment of acute metabolic
acidosis has been very controversial. Ionized
alkaline water was not evaluated in such groups
of patients in spite of its safety and reported
benefits. So, we aimed to assess its efficacy in
the management of metabolic acidosis in animal
models. Two models of metabolic acidosis were
created in dogs and rats. The first model of
renal failure was induced by ligation of both
ureters and the second model was induced by
urinary diversion to gut (gastrointestinal
bicarbonate loss model). Both models were
subjected to ionized alkaline water (orally and
by hemodialysis). Dogs with renal failure were
assigned to two groups according to the type of
dialysate utilized during hemodialysis sessions,
the first was utilizing alkaline water and the
second was utilizing conventional water. Another
two groups of animals with urinary diversion were
arranged to receive oral alkaline water and tap
water. In renal failure animal models, acid-base
parameters improved significantly after
hemodialysis with ionized alkaline water compared
with the conventional water treated with reverse
osmosis (RO). Similar results were observed in
urinary diversion models as there was significant
improvement of both the partial pressure of
carbon dioxide and serum bicarbonate (P 0.007
and 0.001 respectively) after utilizing alkaline
water orally. Alkaline ionized water can be
considered as a major safe strategy in the
management of metabolic acidosis secondary to
renal failure or dialysis or urinary diversion.
Human studies are indicated in the near future to
confirm this issue in humans. PMID 19527469
PubMed - indexed for MEDLINE
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Alkaline ionized water can be considered as a
major safe strategy in the management of
metabolic acidosis secondary to renal failure or
dialysis or urinary diversion. Human studies are
indicated in the near future to confirm this
issue in humans.
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Biomed Res. 2009 Oct30(5)263-9. Electrolyzed-red
uced water inhibits acute ethanol-induced
hangovers in Sprague-Dawley rats. Park SK, Qi
XF, Song SB, Kim DH, Teng YC, Yoon YS, Kim KY, Li
JH, Jin D, Lee KJ. Department of Environmental
Medical Biology, Wonju College of Medicine,
Yonsei University, Wonju, Gangwon, Republic of
Korea. Ethanol consumption disturbs the balance
between the pro- and anti-oxidant systems of the
organism, leading to oxidative stress.
Electrolyzed-reduced water (ERW) is widely used
by people in East Asia for drinking purposes
because of its therapeutic properties including
scavenging effect of reactive oxygen species.
This study was performed to investigate the
effect of ERW on acute ethanol-induced hangovers
in Sprague-Dawley rats. Alcohol concentration in
serum of ERW-treated rats showed significant
difference at 1 h, 3 h and 5 h respectively as
compared with the rats treated with distilled
water. Both alcohol dehydrogenase type 1 and
acetaldehyde dehydrogenase related with oxidation
of alcohol were significantly increased in liver
tissue while the level of aspartate
aminotransferase and alanine aminotransferase in
serum was markedly decreased 24 h after pre-oral
administration of ERW. Moreover, oral
administration of ERW significantly activated
non-ezymatic (glutathione) and enzymatic
(glutathione peroxidase, glutathione-S-transferase
, Cu/Zn-superoxide dismutase and catalase)
antioxidants in liver tissues compared with the
control group. These results suggest that
drinking ERW has an effect of alcohol
detoxification by antioxidant mechanism and has
potentiality for relief of ethanol-induced
hangover symptoms.PMID 19887722 PubMed - in
process
66
Evidence for External Treatment
67
Acid features
68

• Appl Environ Microbiol. 1999 Sep65(9)4276-9.
• Efficacy of electrolyzed oxidizing water for
  inactivating Escherichia coli O157H7, Salmonella
  enteritidis, and Listeria monocytogenes.
• Venkitanarayanan KS, Ezeike GO, Hung YC, Doyle
  MP.
• Department of Animal Science, University of
  Connecticut, Storrs, Connecticut 06269, USA.
• The efficacy of electrolyzed oxidizing water for
  inactivating Escherichia coli O157H7, Salmonella
  enteritidis, and Listeria monocytogenes was
  evaluated. A five-strain mixture of E. coli
  O157H7, S. enteritidis, or L. monocytogenes of
  approximately 10(8) CFU/ml was inoculated in 9 ml
  of electrolyzed oxidizing water (treatment) or 9
  ml of sterile, deionized water (control) and
  incubated at 4 or 23 degrees C for 0, 5, 10, and
  15 min at 35 degrees C for 0, 2, 4, and 6 min
  or at 45 degrees C for 0, 1, 3, and 5 min. The
  surviving population of each pathogen at each
  sampling time was determined on tryptic soy agar.
  At 4 or 23 degrees C, an exposure time of 5 min
  reduced the populations of all three pathogens in
  the treatment samples by approximately 7 log
  CFU/ml, with complete inactivation by 10 min of
  exposure. A reduction of gt 7 log CFU/ml in the
  levels of the three pathogens occurred in the
  treatment samples incubated for 1 min at 45
  degrees C or for 2 min at 35 degrees C. The
  bacterial counts of all three pathogens in
  control samples remained the same throughout the
  incubation at all four temperatures. Results
  indicate that electrolyzed oxidizing water may be
  a useful disinfectant, but appropriate
  applications need to be validated.
• PMID 10473453 PubMed - indexed for MEDLINE

Ionized water kills E Coli, Salmonella and
Listeria
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FAQs

• What happens to alkaline water in the gut
• If I want to alkalize, why cant I just take
  baking soda?
• Can I drink alkaline water with my meals?
• Will acid water (pH 2.5 or 5.5) aid digestion?
• How long will it take to notice the benefits of
  drinking ionized water?
• Can ionized water cure my .?

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How can I get my doctor to listen?

• First, seek to understand
• Doctors are extremely busy, stressed, and have no
  time for the latest healing remedy
• show me the data
• do no harm
• Second, seek to be understood
• Keep it brief and compelling
• Provide data
• Sample water

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Keys to Health and Wellness

• Believe in your bodys ability to heal itself
• Create a healthy mindset
• Manage stress
• Rest, Relax, Laugh, Express Gratitude, Serve
• Move!
• Eat from natures menu (primarily plant-based
  diet)
• Supplement w/ vitamins, anti-oxidants, bHRT
• Drink Ionized Water daily

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Someone said it couldnt be done

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Thank You